Oecd Guideline for the Testing of Chemicals
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چکیده
1. OECD guidelines are available for a wide range of in vitro mutation assays that are able to detect chromosomal and/or gene mutations. However, while in vivo assays in somatic tissues are desirable components of a thorough genetic toxicity testing programme, aside from the little-used (Wahnschaffe et al., 2005) rodent Spot Test (TG 484), OECD guidelines are available only for assays capable of detecting chromosomal aberrations, and not for assays capable of detecting gene mutations. Mammalian Transgenic Rodent (TGR) mutation assays fulfill this need, and will serve as a well-validated and widely-used alternative for the Spot Test that uses much fewer animals and conforms to 3Rs principles of animal usage (reduction, refinement and replacement).
منابع مشابه
Oecd Guideline for Testing of Chemicals Proposal for Revised Introduction to the Oecd Guidelines for Testing of Chemicals, Section 3 Part 1: Principles and Strategies Related to the Testing of Degradation of Organic Chemicals
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تاریخ انتشار 2010